LD_50 (Newbee)
08-09-00 01:01
No 38545
      mda with out sodium cyanoborohydride  Bookmark   

anyone with a good referance or scan of a synth for mda without the use of exotic reducing agents or difficult to obtain chemicals? a semisythetic route from i-safrole or 3,4-methylenedioxyphenylacetone would be great...
 
 
 
 
    Osmium
(Moderator)
08-09-00 02:17
No 38554
      Re: mda with out sodium cyanoborohydride  Bookmark   

Huh?

Look at the thread at the top of this forum. Or search for the Leuckart reaction which uses formamide (from ammonium formate).
 
 
 
 
    Outcast
(Stranger)
08-09-00 23:35
No 38866
      Re: mda with out sodium cyanoborohydride  Bookmark   

An easy way to make MDA from MDP2P is to first make the oxime by reacting the ketone with hydroxylamine-HCl. This can be done in good yields (>90%). See CA -55, 10595 for details.

The formed oxime is reduced by adding a 10 molar excess of sodium pieces to the oxime in anhydrous EtOH. See J. Chem. Soc. Perkin. Trans 2, -97, pp249-56 for a good procedure. This gave 3.2g MDA from about 4g oxime using 6g sodium and 50ml EtOH. If you're interested I can do a write-up on this...
 
 
 
 
    bizwax
(Hive Bee)
08-10-00 00:30
No 38886
      Re: mda with out sodium cyanoborohydride  Bookmark   

You betcha Outcast. We all love new write-ups 'round here. Try to keep in mind a lot of us are just kitchen chemist's. Lookin forward to it cool
 
 
 
 
    Antibody2
(Hive Bee)
08-10-00 06:44
No 38960
      Re: mda with out sodium cyanoborohydride  Bookmark   

LD 50 - check uot the leukart like Osmium says, antibody did alot investigating in that area a while back and is very OTC as well as simple rxn to do. More variations that you can shake a stick at. Antibody is currently tryying to find some of the MW refs which yield MDA or rather the formyl intermediate in MINUTES!

Outcast is that elemental sodium you refer too? Antibody would love to see a write up on that route. Remember reading some proceedures put forth by Rhodium a while back, they sounded abit more involved than what you are proposing.


Jimi loves ya!
 
 
 
 
    LD_50
(Newbee)
08-11-00 12:14
No 39475
      Re: mda with out sodium cyanoborohydride  Bookmark   

yes I did a search of both boards..but could not find any posts that had the rxn. I will check the chemical abstracts this weekend. If somebody has a scan/writeup please post :)
thanks a bunch everyone
 
 
 
 
    foxy2
(Hive Bee)
08-11-00 12:56
No 39482
      Re: mda with out sodium cyanoborohydride  Bookmark   

What will you search CA For
mda with out sodium cyanoborohydride
lol
 
 
 
 
    LD_50
(Newbee)
08-11-00 13:01
No 39484
      Re: mda with out sodium cyanoborohydride  Bookmark   

ok..very funny...
 
 
 
 
    LD_50
(Newbee)
08-11-00 13:10
No 39486
      Re: mda with out sodium cyanoborohydride  Bookmark   

Foxy2: Tell me how you like this CA search string

"getto AND otc AND mda AND cheap AND easy AND reactor AND no sodium cyanaborohydride"-lol

found it!!! JOC, april '88,p4555,

"the getto reaction for producing mda via OTC chemicals"
by: Sloth T. Helvetrochner phd

 
 
 
 
    harry_lime
(Newbee)
08-15-00 05:58
No 41157
      Re: mda with out sodium cyanoborohydride  Bookmark   

Whats happend to outcast ?
Thew writup would have been usefull.


I just couldn,t resist asking !
 
 
 
 
    Sonson
(Stranger)
08-15-00 23:42
No 41469
      Re: mda with out sodium cyanoborohydride  Bookmark   

Heh, this is outcast with my original alias (sonson). I had some problems with my account. And the writeup...almost done...just have to make my dreams more colourful...add more details. Hang on...
 
 
 
 
    harry_lime
(Newbee / Eraser)
09-02-00 04:41
No 48106
      Re: mda with out sodium cyanoborohydride  Bookmark   

Still hangin !


I just couldn,t resist asking !
 
 
 
 
    frost
(Hive Bee)
09-03-00 11:02
No 48472
      Re: mda with out sodium cyanoborohydride  Bookmark   

were hangin as well outcast, this sounds pretty intresting!
frost
 
 
 
 
    tomjuan
(Hive Bee)
11-28-01 07:17
No 241619
      Re: mda with out sodium cyanoborohydride  Bookmark   

This document on Rhodium's site ../rhodium/chemistry /mda.dalcason.html seems to imply that MDP2P can converted to MDA in one step, using ammonia and either the amalgam method or the Raney Nickel method. Is this not the case?
 
 
 
 
    Rhodium
(Chief Bee)
11-28-01 07:28
No 241624
      Re: mda with out sodium cyanoborohydride  Bookmark   

The amalgam route using ammonia (or ammonium salts) is very low-yielding (20-30%), I don't know about the catalytic hydrogenation with Ni though.
 
 
 
 
    zooligan
(Hive Addict)
11-28-01 11:16
No 241692
      Re: mda with out sodium cyanoborohydride  Bookmark   

Raney requires high pressure (supposedly).  There's a link on your (Rhod) page which is a compendium of journal articles.  One is from a Russian Law Enforcement journal detailing how a lab there made MDA using high-pressure CTH.

z

"And if we don't get some cool rules ourselves, pronto, then we'll just be bogus too!"
 
 
 
 
    cheeseboy
(Hive Bee)
12-09-01 19:15
No 245992
      Re: mda with out sodium cyanoborohydride  Bookmark   

TETRANITROMETHANE!!!!!  BOOOOOM!!!

May The Source Bee With Yous