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Novel PCP analog
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Author Topic: Novel PCP analog
Member posted 10-21-1999 03:37 AM
I recently heard an anonymous report about a PCP analog that has not been previously tested in humans. The compound was N-propyl-1-(2-thienyl)-cyclohexylamine, i.e. the analog of PCP with thiophene replacing benzene and an n-propyl amino group replacing the piperidine ring.
This compound is an interesting analog since it has a thiophene ring as well as a short N-alkyl group, both substitutions known to increase potency of PCP.
It was synthesized under very primative conditions by the imine route generally described in the PCP faq with a small modification:
Cyclohexanone and n-propylamine were stirred at RT for 48 hr in toluene with anhydrous Mg sulfate to form the imine. The salt was filtered, and excess 2-thienyl lithium was added dropwise at 0 deg., followed by heating to reflux briefely. The reaction was quenched with water and the final product isolated by acid/base extraction.
Yield was very dissapointing, probably due to use of ancient commercial 2-thienyllithium that was partially decomposed.
Unfortunately when the compound was vaporized and inhaled it turned out to be quite a bit less actve than PCP itself. In the future, higher dosages might be assayed to better define the potency, but it seems surprisingly low.
The most active PCP analogs have small N-alky groups: activity peaks at ethyl, but potency doesn't seem to drop off so fast on going from ethyl to propyl in the phenyl analogs (PCE and PC-n-Pr). At least that's what animal tests seem to indicate.
Bummer, but as they say, negative results are still results.
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