dormouse (Member)
04-19-00 18:19
No 122813
      Oxygenated Tryptamines w/ LSD Activity incorp a Chiral Pyridine Moiety -Acme  Bookmark   


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Author  Topic:   Oxygenated Tryptamines w/ LSD Activity incorp a Chiral Pyridine Moiety 
Acme
Member   posted 12-07-1999 01:48 PM          
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J. Med. Chem. 1999, 42, 4257
The paper reveals that this class of compounds (made from 5-MeO-bromo-indole lithium anion and N-methyl proline O-methyl ester, then reduce carbonyl) , are ten-fold less active than LSD, but have activity comparable to DOI. Speculate that the compounds may have LSD-like effect in man.


Slappy
Moderator   posted 12-08-1999 05:49 AM          
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Actually, its "...Chiral Pyrrolidine Moiety...". Anyway, it is a very interesting article. I believe Rhodium mentioned it a while ago.
 
Nemesis
Member   posted 12-12-1999 04:05 PM          
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I've also mentioned this same article in fact I was going to post the synthesis procedures mentioned there on DMT World:
<A HREF="http://dmt.lycaeum.org/ncgi/Forum6/HTML/000217.html"%3B>%3BSubstituted 3-(N-methylpyrrolidin-2-ylmethyl)-indoles with LSD-like activity!</A>

Check out some of my other posts, too!

-Nemesis


Acme
Member   posted 12-13-1999 01:58 PM          
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Sorry about the pyridine mistake, fellow-bees.
 
Slappy
Moderator   posted 12-13-1999 11:32 PM          
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Simple mistake, no need to apologize.
 
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