Bwiti (Hive Addict)
08-30-01 08:42
No 208540
      Water Soluble THC ? ?  Bookmark   

What's up folks?! I enjoy smoking my weed until i'm stoned out of my fucking mind, but wouldn't it be neat if you could extract the THC and other cannabinoids from your dope and convert it into water soluble dope? That way you could snort it, main-line it and muscle it. That would be a cool alternative if your lungs and throat have taken a beating from heavy use. Any ideas or patent #'s would be much appreciated. Peace and happy cooking!cool

  I'm going to help all of you cleanse this diseased planet.
(Stranger / Eraser)
08-30-01 13:38
No 208606
      Re: Water Soluble THC ? ?  Bookmark   

first of all mainline etc? wtf u up about its weed 2, thc is water sol in a slightly acid solution at about 200+c

some people call me lazy
worldly wise i realize that everybodys crazy
(Hive Addict)
08-30-01 13:57
No 208610
      Re: Water Soluble THC ? ?  Bookmark   

There is a thread on injecting THC at Bluelight in the other drugs forum.  The posters are not that bright but are trying crazy

It does not necessarily need to bee soluable to inject(maybee, this is not a known fact, if you kill yourself it ain't my fault)  Many steroids are not water soluable but they are injected.  I forget what solvent they use but low solubility compounds can be injected.

Is smokeing not fast enough?

Do Your Part To Win The War
(Hive Addict)
08-30-01 20:41
No 208694
      Re: Water Soluble THC ? ?  Bookmark   

the point is to provide a less health-depriving method of administration for the drug. we aren't complaining about the speed of action.  and what good does it do to have water soluble THC if it's in acid @ 200*C? ouch.
(Hive Addict)
08-30-01 20:56
No 208699
      Re: Water Soluble THC ? ?  Bookmark   

The point is not water soluable THC it is what solvents can you safely shoot.

Comparitive hemolytic activity of undiluted organic water-miscible
solvents for intravenous and intra-arterial injection.

PDA J Pharm Sci Technol 55(1): 16-23 Jan-Feb 2001

Abstract:    In humans, nonaqueous solvents are administered intravascularly
in two kinds of situations. they have been used in subcutaneous or
intramuscular pharmaceutical formulations to dissolve water-insoluble
drugs. The need for these vehicles had increased in recent years,
since the drug development process has yielded many poorly
water-soluble drugs. The use of water-miscible nonaqueous solvents
is therefore one of the approaches for administering these products
as reference solutions useful in formulation bioequivalence studies.
The intravascular use of organic solvents has also gained importance
owing to a new approach for the treatment of  cerebral malformations
using precipitating polymers dissolved in water-miscible organic
solvents. At present, the solvent most commonly used for the liquid
embolics to solubilize the polymers is dimethyl sulfoxide , which
exhibits some local and hemodynamic toxicities. In order to find new,
less toxic vehicles for phamaceutical formulations for the intravenous
and intra-arterial routes and for embolic materials, 13 water-miscible
organic solvents currently used (diluted with water) for pharmaceutical
applicaitons, werre evaluated in this study. Their  hemolytic activity
and the morphological changes induced when mixed with blood
(1:99, 5:95, 10:90 solvent:blood) were estimated in vitro. From these
data, the selected organic solvents could be subdivided into four
groups depending on their hemolytic activity: very  highly hemolytic
solvents (ethyl lactate, dimethyl sulfoxide), highly hemolytic solvents
(polyethyene glycol 200, acetone), moderately hemolytic solvents
(tetrahydrofurfuryl alcohol, N-methyl-2-pyrrolidone, glycerol formal,
ethanol, Soketal, glycofurol) and solvents with low hemolytic activity
(propylene glycol, dimethyl isosorbide, diglyme).
(Hive Addict)
08-30-01 20:59
No 208701
      Re: Water Soluble THC ? ?  Bookmark   

Each 5 mL ampoule contains :
Etoposide 100 mg
Citric acid 10 mg
Benzyl alcohol 150 mg
Polysorbate 80 (Tween 80) 400 mg
Polyethylene glycol 300 (Macrogol 300) 3 250 mg
Absolute ethanol qs to 5 mL

Do Your Part To Win The War
(Hive Elder)
08-30-01 23:22
No 208758
      Re: Water Soluble THC ? ?  Bookmark   

If health concious is what your looking for then why not just eat it...?

crazylaughsmiletonguewink    Mean People Suck    winktonguesmilelaughcrazy
(Hive Addict)
08-31-01 00:29
No 208783
      Re: Water Soluble THC ? ?  Bookmark   

ok Semtexium, there's a give and take between health and speed of onset (this is for another person's tastes- not obit's)  for obit, the oral ingestion would be fine.
(Hive Addict)
08-31-01 00:38
No 208785
      Re: Water Soluble THC ? ?  Bookmark   

go to the US patent office and search for THC acetate.  there is an excellent writeup there on a group that develoved a water soluble acetate form of THC for nasal administration.  The idea was kickass, and they seemed to get really good results from it as well.

Drunk driving, that's what I like to do,
I like drunk driving with you.
(Hive Addict)
08-31-01 07:46
No 208893
      Re: Water Soluble THC ? ?  Bookmark   

Cool, I found a shit-load of THC acetate info at . An easier way would be to just mix your hash with alcohol, water and propylene glycol, then muscle it. That shouldn't be any more painful than muscling shitty crank. DMSO's kind of toxic, but only a little would be needed, so I think it's worth trying. Smoking is fine, except for soarness, but I love injecting almost any drug. Peace!cool

  I'm going to help all of you cleanse this diseased planet.
(Hive Bee)
09-04-01 18:31
No 210038
      Re: Water Soluble THC ? ?  Bookmark   

Bwiti, how do you perform a search on "THC acetate" in that page? With string it always returns me "No Results" frown
Can you help me out?

Chemically enhanced.
(Hive Addict)
09-04-01 20:00
No 210064
      Re: Water Soluble THC ? ?  Bookmark   

  Here are some acetate/ester patents and others that I find interesting:
Method of preparing delta-9-tetrahydrocannabinol esters
Method of preparing delta-9-tetrahydrocannabinol esters
(3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions
Certain tetrahydrocannabinol-7-oic acid derivatives
(3R,4R)- DELTA 6-tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
Synthesis of 11-nor- DELTA -9-tetrahydrocannabinol-9-carboxylic acid glucuronide

Peace and happy cooking!cool

  I'm going to help all of you cleanse this diseased planet.
(Mega Meth Man)
10-17-01 02:36
No 225467
      Re: Water Soluble THC ? ?  Bookmark   

Hey there- swix seems to recall an entry in that old seminal work, "Psychedelic Chemistry", to the effect that THC in benzene or MeCl2 was allowed to react with a slight molar excess of di-cyclohexylcarbodiimide at approximateely room temp, with stirring.  The claimed result was a water soluble addition product of unknown activity.

No matter where you go, there you are.....
(Hive Bee)
10-17-01 13:38
No 225755
      Re: Water Soluble THC ? ?  Bookmark   

There are also injectable steroids that use water as a base (oil leaves that bolus - it hurts, damnit!) - it's called a suspension....
For any questions on solvents for injections of non-water soluble substances (NEVER EVER IV them - IM/SC them, please!) I will refer you to Dan Duchaine.
If you don't know who he is, UTFSE! (Stonium, can we get your picture for this stuck at the bottom like the smileys? It would be so cool!)
(Hive Addict)
10-17-01 14:19
No 225761
      Re: Water Soluble THC ? ?  Bookmark   


  I'm a firm believer that anything with a cyclohexyl should be reserved for the production of PCP-analogs.laugh
Don't listen to anything Valentine says in "Psychedelic Chemistry"; Find the references he provides, and pay attention only to those.

"it's called a suspension...."

  When I was a pathetic benzodiazepine/booze junky, I used to go to the emergency room with panic attacks when I ran-out, and sometimes they'd give me an IM of ativan suspension. Damn straight it hurts!

  How else could one ingest their dope, besides eating/smoking/slamming/IMing? Push two joints up your ass or make a snuff and snort it. We're out of holes to put this stuff in, unless someone here's willing to try shoving it in their eyes or sex organ!laugh

  I'm going to help all of you cleanse this diseased planet.
(Hive Bee)
10-21-01 03:55
No 227356
      Re: Water Soluble THC ? ?  Bookmark   

Dicyclohexylcarbodiimide is a very common amide coupling reagent. Usually used in peptide synthesis.
01-14-03 02:08
No 397919
      acetate  Bookmark   

 on one of the threads posted hash oil by sasser
 one of the reply posts talk about thc acetation form a powder although SWIM has not tried this method sounds viable as a snorting agent
if you love being stoned most of your time try anandamide or something maybee anandamide is injectable dont know till you do your research UTFSE
HAVE FUNcrazycoollaughsmilewink
01-15-03 01:58
      just cook down a resin ball....
(Rated as: insignificant)