Rhodium (Chief Bee)
11-13-01 07:57
No 236155
      Grignard - Large scale?  Bookmark   

Is the grignard reaction ever used on an industrial scale, or is it only used on laboratory scale, up to a kilogram?
 
 
 
 
    abc123
(Hive Bee)
11-15-01 01:34
No 236818
      Re: Grignard - Large scale?  Bookmark   

I think they would have to be if ketamine is as available as it is. After all dosen't it's preparation require a Grignard reaction? It's just a thought...wink

Calamus

Dad made whisky and he made it well, cost two dollars....burned like hell......GD
 
 
 
 
    foxy2
(Distinctive Doe)
11-15-01 04:38
No 236881
      Re: Grignard - Large scale?  Bookmark   

Yes they are scaled up. 

http://www.teknoarticles.com/co/2000/comay/2patter.htm




I want a nice argumentative thread, where I can tear little Bee's wings off smile
 
 
 
 
    wareami
(Hive Bee)
11-15-01 05:00
No 236886
      Re: Grignard - Large scale?  Bookmark   

foxy2 answered yer question...don't know but this may be of some use too. http://www.longchemical.com/products/aromatics/aromatics.htm
http://www.longchemical.com/products/heterocycle/heterocycle.htm
Peacecool
Have Fun-Bee Safe

Youth and skill are no match for experience and treachery.

˘┐˘Wareami
 
 
 
 
    Scooby_Doo
(Hive Bee)
11-17-01 03:27
No 237552
      Re: Grignard - Large scale?  Bookmark   

Yes it is used very effectively in industry. I believe many patents have been submitted on industrial sized methods for continuous batch production. However Victor's 3 stage production method still seems to be the most preferred route.

The 3 stages being, the Grignard creation in the first vessel. Then the complex is pumped and filtered to the second vessel were it is reacted with the other reagent. The solvent is distilled off to a storage vessel for reuse. A suitable solvent usually toluene is added and the Magnesium salt is then pumped to a third vessel were it is hydrolysed (if necessary).

The vessels construction can be carbon steel but stainless steel is preferred. The third vessels is usually a glass lined steel vessel.