Solvent for EtBr + NaNO2 -> Nitroethane , Hive Chemistry Discourse
 
    SpicyBrown (Hive Bee) 12-23-01 15:38 No 250119       Solvent for EtBr + NaNO2 -> Nitroethane </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250119&Number=250119&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> In <a href="http://chemistry.mdma.ch/hiveboard/rhodium/chemistry /nitroalkane.html" target="_blank" title="Jump to this external site">../rhodium/chemistry /nitroal<wbr>kane.htm<wbr>l</a> regarding the synthesis of Nitrothethane from Ethyl Bromide and Sodium Nitrite, the text says DMSO can be used in place of DMF. For 32.5 grams of Ethyl Bromide they suggest 600ml DMF. How much DMSO would be used in it's place? <br><br>Thanks,<br>SpicyBrown<br> </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> <td align="left" valign="top" class="text_bg"> <img src="../forum/images/left_top.gif" border="0" height="12" width="9"></td> <td colspan="7"><a name="Post250121"></a></a> </td> <td align="right" valign="top"><img src="../forum/images/right_top.gif" border="0" height="12" width="9"></td> </tr> <tr class="text_bg"> <td rowspan="2"> </td> <td rowspan="2"> </td> <td valign="top" align="center" rowspan="2"> <font color="#ff0000">lugh</font><br> <i>(<span title="The user's title at the time of posting">Hive Bee</span>)</i><br> <span title="Posting date">12-23-01 15:58</span><br> <span title="Link to this post by using the markup [250121]">No 250121</span><br> </td> <td rowspan="2">  </td> <td rowspan="2" width="1" class="vert_ruler"> <img src="../forum/images/hr.gif" border="0" width="1" height="1"> </td> <td rowspan="2">  </td> <td class="text_bg" align="left" valign="top"> <title>Re: Solvent for EtBr + NaNO2 -> Nitroethane </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250121&Number=250121&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> Kornblum's synthesis of nitro compounds {<i>JACS</i> <b>78 1497 (1955)} was done using dimethylformamide, primarily because of sodium nitrite's solubility in that solvent. Kornblum writes in note 10 that Mr. Hardles discovered that the same reaction occured in dimethyl sulfoxide just before publication, and that sodium nitrite was more soluble in dimethyl sulfoxide than dimethylformamide. Thus, unless some bee has actually done this and cares to tell you about it, you are going to have to determine this fact for yourself. Please let us know once you find out <img src="../forum/images/icons_lightgrey/smile.gif" alt="smile" title="Smile" heigth="15" width="15"> </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> <td align="left" valign="top" class="text_bg"> <img src="../forum/images/left_top.gif" border="0" height="12" width="9"></td> <td colspan="7"><a name="Post250127"></a></a> </td> <td align="right" valign="top"><img src="../forum/images/right_top.gif" border="0" height="12" width="9"></td> </tr> <tr class="text_bg"> <td rowspan="2"> </td> <td rowspan="2"> </td> <td valign="top" align="center" rowspan="2"> ChemicalSolution<br> <i>(<span title="The user's title at the time of posting">Stranger</span>)</i><br> <span title="Posting date">12-23-01 16:17</span><br> <span title="Link to this post by using the markup [250127]">No 250127</span><br> </td> <td rowspan="2">  </td> <td rowspan="2" width="1" class="vert_ruler"> <img src="../forum/images/hr.gif" border="0" width="1" height="1"> </td> <td rowspan="2">  </td> <td class="text_bg" align="left" valign="top"> <title>Re: Solvent for EtBr + NaNO2 -> Nitroethane</b> </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250127&Number=250127&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> The solubility of NaNO2 in DMSO is 20g per 100ml however in the CA publication, 250ml was used per 36g(0.52 mole) NaNO2 with 0.29 mole alkyl halide.  <br><br>All of the examples used were larger alkyl halides.  I know someone who would be interested to see how it works with ET-Br.  Anyway, most of the yields with DMF were a little lower than DMSO and the reaction time was considerably shorter with the DMSO route.  Apparently the dryness of the reaction plays a huge role with secondary alkyl halides but "not much of one" with primary halides.  So heathfood store DMSO would probably work fine.. Now if it wasn't so damn expensive!! </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> <td align="left" valign="top" class="text_bg"> <img src="../forum/images/left_top.gif" border="0" height="12" width="9"></td> <td colspan="7"><a name="Post250137"></a></a> </td> <td align="right" valign="top"><img src="../forum/images/right_top.gif" border="0" height="12" width="9"></td> </tr> <tr class="text_bg"> <td rowspan="2"> </td> <td rowspan="2"> </td> <td valign="top" align="center" rowspan="2"> terbium<br> <i>(<span title="The user's title at the time of posting">Old P2P Cook</span>)</i><br> <span title="Posting date">12-23-01 17:50</span><br> <span title="Link to this post by using the markup [250137]">No 250137</span><br> </td> <td rowspan="2">  </td> <td rowspan="2" width="1" class="vert_ruler"> <img src="../forum/images/hr.gif" border="0" width="1" height="1"> </td> <td rowspan="2">  </td> <td class="text_bg" align="left" valign="top"> <b title="The subject of this post">Re: Solvent for EtBr + NaNO2 -> Nitroethane</b> </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250137&Number=250137&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> <font color="blue">So heathfood store DMSO would probably work fine.. Now if it wasn't so damn expensive!! </font color="blue"><br>Gee, I just did a little search of the Internet and found 99.9% DMSO offered for sale for less than $40.00/gallon. </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> <td align="left" valign="top" class="text_bg"> <img src="../forum/images/left_top.gif" border="0" height="12" width="9"></td> <td colspan="7"><a name="Post250138"></a></a> </td> <td align="right" valign="top"><img src="../forum/images/right_top.gif" border="0" height="12" width="9"></td> </tr> <tr class="text_bg"> <td rowspan="2"> </td> <td rowspan="2"> </td> <td valign="top" align="center" rowspan="2"> ChemicalSolution<br> <i>(<span title="The user's title at the time of posting">Stranger</span>)</i><br> <span title="Posting date">12-23-01 18:00</span><br> <span title="Link to this post by using the markup [250138]">No 250138</span><br> </td> <td rowspan="2">  </td> <td rowspan="2" width="1" class="vert_ruler"> <img src="../forum/images/hr.gif" border="0" width="1" height="1"> </td> <td rowspan="2">  </td> <td class="text_bg" align="left" valign="top"> <b title="The subject of this post">Re: Solvent for EtBr + NaNO2 -> Nitroethane</b> </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250138&Number=250138&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> LOL.  After you fractionally distill nearly 1/3 volume of water off you will have a decent solvent.  Still, it's cheaper than the healthfood store stuff.  One has to wonder how *they* can sell "99.9%" DMSO at a fraction of the price of that from reputable sellers. </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> <td align="left" valign="top" class="text_bg"> <img src="../forum/images/left_top.gif" border="0" height="12" width="9"></td> <td colspan="7"><a name="Post250139"></a></a> </td> <td align="right" valign="top"><img src="../forum/images/right_top.gif" border="0" height="12" width="9"></td> </tr> <tr class="text_bg"> <td rowspan="2"> </td> <td rowspan="2"> </td> <td valign="top" align="center" rowspan="2"> terbium<br> <i>(<span title="The user's title at the time of posting">Old P2P Cook</span>)</i><br> <span title="Posting date">12-23-01 18:03</span><br> <span title="Link to this post by using the markup [250139]">No 250139</span><br> </td> <td rowspan="2">  </td> <td rowspan="2" width="1" class="vert_ruler"> <img src="../forum/images/hr.gif" border="0" width="1" height="1"> </td> <td rowspan="2">  </td> <td class="text_bg" align="left" valign="top"> <b title="The subject of this post">Re: Solvent for EtBr + NaNO2 -> Nitroethane</b> </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250139&Number=250139&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> <font color="blue">After you fractionally distill nearly 1/3 volume of water off you will have a decent solvent.</font color="blue"><br>???<br><br>DMSO is cheap stuff. It is a byproduct.<br><br><font color="red">edit:</font color="red"><br>I just found another Internet site selling 99.9% DMSO for a little over $40/gallon </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> <td align="left" valign="top" class="text_bg"> <img src="../forum/images/left_top.gif" border="0" height="12" width="9"></td> <td colspan="7"><a name="Post250140"></a></a> </td> <td align="right" valign="top"><img src="../forum/images/right_top.gif" border="0" height="12" width="9"></td> </tr> <tr class="text_bg"> <td rowspan="2"> </td> <td rowspan="2"> </td> <td valign="top" align="center" rowspan="2"> <font color="#ff0000">lugh</font><br> <i>(<span title="The user's title at the time of posting">Hive Bee</span>)</i><br> <span title="Posting date">12-23-01 18:04</span><br> <span title="Link to this post by using the markup [250140]">No 250140</span><br> </td> <td rowspan="2">  </td> <td rowspan="2" width="1" class="vert_ruler"> <img src="../forum/images/hr.gif" border="0" width="1" height="1"> </td> <td rowspan="2">  </td> <td class="text_bg" align="left" valign="top"> <b title="The subject of this post">Re: Solvent for EtBr + NaNO2 -> Nitroethane</b> </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250140&Number=250140&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> If it's 99.9% dimethylsulfoxide how can it be 1/3 water?<br>Dimethyl sulfoxide is generally treated with a drying agent prior to vacuum distillation, sodium hydroxide pellets have been used sucessfully <img src="../forum/images/icons_lightgrey/smile.gif" alt="smile" title="Smile" heigth="15" width="15"> </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> <td align="left" valign="top" class="text_bg"> <img src="../forum/images/left_top.gif" border="0" height="12" width="9"></td> <td colspan="7"><a name="Post250146"></a></a> </td> <td align="right" valign="top"><img src="../forum/images/right_top.gif" border="0" height="12" width="9"></td> </tr> <tr class="text_bg"> <td rowspan="2"> </td> <td rowspan="2"> </td> <td valign="top" align="center" rowspan="2"> ChemicalSolution<br> <i>(<span title="The user's title at the time of posting">Stranger</span>)</i><br> <span title="Posting date">12-23-01 18:55</span><br> <span title="Link to this post by using the markup [250146]">No 250146</span><br> </td> <td rowspan="2">  </td> <td rowspan="2" width="1" class="vert_ruler"> <img src="../forum/images/hr.gif" border="0" width="1" height="1"> </td> <td rowspan="2">  </td> <td class="text_bg" align="left" valign="top"> <b title="The subject of this post">Re: Solvent for EtBr + NaNO2 -> Nitroethane</b> </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250146&Number=250146&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> Once you buy that 99.9% DMSO you'll see how it can be 1/3 water.  Don't bother asking for a certificate of analysis from them.  If you have a dealer that sold you 99.9% DMSO for $40/gallon then more power to you.  If you haven't used it yet, you might try distilling to make sure.  I know someone who used the bargain DMSO and ruined a batch.  Later found out it really wasn't 99.9%.  See if it freezes if your fridge. </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> <td align="left" valign="top" class="text_bg"> <img src="../forum/images/left_top.gif" border="0" height="12" width="9"></td> <td colspan="7"><a name="Post250286"></a><a name="last"></a></a> </td> <td align="right" valign="top"><img src="../forum/images/right_top.gif" border="0" height="12" width="9"></td> </tr> <tr class="text_bg"> <td rowspan="2"> </td> <td rowspan="2"> </td> <td valign="top" align="center" rowspan="2"> SpicyBrown<br> <i>(<span title="The user's title at the time of posting">Hive Bee</span>)</i><br> <span title="Posting date">12-24-01 11:45</span><br> <span title="Link to this post by using the markup [250286]">No 250286</span><br> </td> <td rowspan="2">  </td> <td rowspan="2" width="1" class="vert_ruler"> <img src="../forum/images/hr.gif" border="0" width="1" height="1"> </td> <td rowspan="2">  </td> <td class="text_bg" align="left" valign="top"> <b title="The subject of this post">Re: Solvent for EtBr + NaNO2 -> Nitroethane</b> </td> <td class="text_bg" align="right" valign="top">  <a href="https://www.the-hive.ws/forum/favorites.pl?Cat=&option=add&number=250286&Number=250286&page=82&view=&sort=5&part=&vc=&new=&backto=showflat" title="Add this post to your bookmark list in your Private Area">Bookmark</a>  </td> <td> </td> </tr> <tr class="text_bg"> <td colspan="2" valign="top" align="left"> <br> Thanks everybody for your input! SWIM will of course report back here with results should they surface..<br><br>SpicyBrown<br> </td> <td> </td> </tr> <tr class="text_bg"> <td align="left" valign="bottom"><img src="../forum/images/left_bottom.gif" border="0" height="12" width="9"></td> <td valign="middle" align="center" colspan="7"> </td> <td align="right" valign="bottom"><img src="../forum/images/right_bottom.gif" border="0" height="12" width="9"></td> </tr> <tr class="page_bg"> <td colspan="9"> </td> </tr> </body> </html>