Chromic (Hive Addict)
02-23-02 21:29
No 272587
      Reducing aryl alkyl carbonyls  Bookmark   

Well, in my studies I crossed a reduction of aryl alkyl carbonyls (maybe best called benzylic carbonyls?) to aryl akyls, which sort of surprised me because it used H2/Pd giving the same ends as the Wolf-Kishner which has been talked about in Post 172398 (rubberneck: "Wolff-Kishner reduction", Stimulants) but with nearly 100% yields. Anyone tried this on methcathinone or Wellbutrin?
(Pioneer Researcher)
02-23-02 22:29
No 272625
      Re: Reducing aryl alkyl carbonyls  Bookmark   

CTH reduces carbonyls too, and seems more accesible.
(Chief Bee)
02-24-02 04:19
No 272741
      Re: Reducing aryl alkyl carbonyls  Bookmark   

True, CTH seems like it is good for almost anything. BTW, the Wolff-Kishner reduction can be carried out in the microwave in 1-2 minutes, I can dig up the ref if you want to.

I don't think the Wolff-Kishner reduction works well with vicinal aminoketones (as in methcathinone) though, as they can self-condense to unusable pyrazines under basic conditions.