PolytheneSam (Master Searcher)
03-04-02 02:42
No 276458
      Benzothiophene analogs  Bookmark   

You can look up analogue here.  http://www.m-w.com

I found two articles in the Journal of Medicinal Chemistry on benzothiophene analogs of tryptamines.  They mention that the N-H in the indole ring in tryptamines aren't important in receptor binding.  They also give a synthesis of the dimethyltryptamine analog (S in place of N-H in the indole ring) from the tryptamine analog using formaldehyde and formic acid Post 248013 (PolytheneSam: "Re: Leuckart alkylation", Newbee Forum) .  Does anyone have any info about psychoactive properties?

1) Sept. 1968 pages 1049-1054
2) Vol. 13, No. 6, 1970, pages 1205-1208

Also see http://us.f1.yahoofs.com/users/4212977f/bc/Leuckart+Reaction/Leuckart307.tif?bc_dtg8ARDFKndoC