Vibrating_Lights (Hive Bee)
03-11-02 05:31
No 280408
      Tma from Tmma  Bookmark   

Tfse yeilded  aset of pallendrome posts.  SWim is looking for a way to remove the Methyl leaving NH2 that would be suitable for use with a slew of Methoxys to worry about.
VL_
 
 
 
 
    PrimoPyro
(Hive Prodigy)
03-11-02 05:32
No 280409
      Re: Tma from Tmma  Bookmark   

I dont understand your reasoning or plan behind this. Where is the TMMA coming from?

Vivent Longtemps La Ruche!
 
 
 
 
    Chromic
(Hive Addict)
03-11-02 05:53
No 280428
      Re: Tma from Tmma  Bookmark   

TMMA-2 is quite boring, even at 250mg so I see your reason to remove that N-methyl group.

TMA-2 is much more interesting, but still, high doses are recommended (~80mg is fun). You should form the NH3 imine and reduce or form the NH2OH ketoxime and reduce, do not bother with forming the N-methyl derivative then trying to cleave the group.

Good luck with everything.
 
 
 
 
    Vibrating_Lights
(Hive Bee)
03-11-02 06:46
No 280464
      Re: Tma from Tmma  Bookmark   

Swims friens were board and wont have any hydroxlamine for a week and wanted to scheme up some visuals for the weekend.  The Tmma is Vl_'s secret for now until it is properly exploited. Possible Completely Otc 55%overall yeild synth with no NaBH4 or exotic shit,  I'm sure chromic Knows what i'm talking about don't tell em yet. TeeHee
VL_
 
 
 
 
    Flinger
(Hive Bee)
03-11-02 07:43
No 280501
      Re: Tma from Tmma  Bookmark   

um from whatever precursors [very cheap] um ussing the zinc and finally heating that up in ammonial alkali.  Sounds easy perhaps other novel more natural starting meterials will yield more potent variations.
 
 
 
 
    otto
(Newbee)
03-11-02 20:34
No 280716
      Re: Tma from Tmma  Bookmark   

hi chromic,

may i adress some questions to you?
first is: 80 mgs TMA-2 sounds pretty hardcore, what about bodyloud. can you give a report eventually?
second: otto has unexpectedly difficulties in getting TMA-2 from ketone using NH3 in MeOH and Pd/C - Hydrogenation. ammonium acetate in MeOH with MgSO4/silica gel and NaBH4 was dreamed of, but work-up is still to be done.
what procedure would you suggest?

otto
 
 
 
 
    Rhodium
(Chief Bee)
03-11-02 21:05
No 280728
      Re: Tma from Tmma  Bookmark   

I cannot think of ANY practical method for removing the methyl group of TMMA. 
 
 
 
 
    PolytheneSam
(Master Searcher)
03-11-02 21:22
No 280740
      Re: Tma from Tmma  Bookmark   

Maybe NH3 and Ni would work, ie. the NH3 would have to replace the MeNH2 in the imine.  Post 43613 (CHEM_GUY: "Text implies Possible isomerization of l-meth", Chemistry Discourse) Post 75995 (PolytheneSam: "Re: Text implies Possible isomerization of l-meth", Chemistry Discourse)

http://www.geocities.com/dritte123/PSPF.html
 
 
 
 
    Vibrating_Lights
(Hive Bee)
03-12-02 02:14
No 280872
      Re: Tma from Tmma  Bookmark   

Otto:
By what method did you make the ketone.
Any way make the Oxime with hydroxlamine  then do an acidic Al/Hg of the oxime with 10eq. of AcOH in EtOH.  put all of the oxime in then add preamalgamated Al dropwise.  that should work.  you'll lose a small portion of the methoxys.
VL_
 
 
 
 
    Chromic
(Hive Addict)
03-12-02 04:59
No 280978
      Re: Tma from Tmma  Bookmark   

Yeah, the body load was very harsh from TMA-2. TMMA-2 did not have nearly as much body load, it was much lighter like DMMDMA-2, although slightly more confusing (my thoughts were confused) at similar dosage levels (250mg).

My heart rate hit 120 bpm and the good visuals did not kick in until ~3hrs at 75mg of TMA-2, the body load was heavy, dancing was not really possible but sitting around and talking was lots of fun. At the time I had no realization that I was so high (in retrospect it become obvious). The confusion was absolutely PROFOUND. Still, it lacked the visuals I'm used to with good LSD. Pupil dilation was not as strong as what 100mg of MDMA does to me, although they were definitely dilated.

I've heard of a much respected bee who thought 150mg of TMA-2 was absolutely enjoyable. Not quite for me, but I'd feel comfortable pushing it further than 75mg. I'm not sure what route is best. I've been going after reducing the ketoxime made from a peracetic, but I haven't had much good luck.
 
 
 
 
    hest
(Hive Bee)
03-12-02 11:12
No 281146
      Re: Tma from Tmma  Bookmark   

The fun starts at 1.2mg/kg.
Why not just use the old leuchart ??../rhodium/archive/leuckart.pdf
 
 
 
 
    otto
(Newbee)
03-12-02 21:07
No 281384
      Re: Tma from Tmma  Bookmark   

thanx Vibrating_Lights,

otto will try to get some NH2OH then.
the ketone was made in 2 steps from asarone (vak-dest from indian oil of calamus). first was osmium - catalysed dihydroxylation (sharpless-dihydroxylation, non-chiral), which gave the diol as an almost white solid and second 2 hours @ 80C in 15% H2SO4. the resulting Ketone was not totally clean (as indicated by TLC). it had a pleasant smell reminiscent to that of bananas, when they are already sparkled with black spots.

TLC - data (petrol ether/ethyl acetate 4:1):

asarone     0,55
diol        0
ketone      0,2

otto
 
 
 
 
    Precursor2112
(Hive Bee)
03-18-02 00:34
No 284022
      Re: Tma from Tmma  Bookmark   

Okay...whats TMA-2 like....

 
 
 
 
    Rhodium
(Chief Bee)
03-18-02 01:29
No 284042
      Re: Tma from Tmma  Bookmark   

TMA-2:

http://www.erowid.org/library/books_online/pihkal/pihkal158.shtml