malvaxman (Hive Bee)
05-22-02 01:47
No 312192
      Is there any method...  Bookmark   

Is there any method to make pure enantiomeric d-meth which doesn´t involve natural products like l-ephedrine l-PAC?

....i guess the method which ofcours exists could be applicable in some research fascility but deffinitly not my kitchen or garage. crazy

/Thank you for your help
 
 
 
 
    Rhodium
(Chief Bee)
05-22-02 01:55
No 312199
      Resolution instructions  Bookmark   

../rhodium/chemistry /amphetamine.resolution.html
 
 
 
 
    PrimoPyro
(Hive Prodigy)
05-22-02 02:06
No 312205
      Just putting the word out  Bookmark   

There are also likely to be other possibilities involving organometallic syntheses. Many chiral agents have been developed for many syntheses involving these reactions. More information, I cannot produce, this is essentially all I know. My source (March's 5th) was very vague, and only consisting of about two sentences stating what I already stated.

Many of these catalysts revolve around the syntheses of alcohols and amines, so it is likely that such methods exist and are applicable here. What they are, I do not know as of yet.

                                                   PrimoPyro

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    lugh
(Moderator)
05-22-02 02:16
No 312212
      Methylbenzylamine  Bookmark   

You can also use reductive alkylation using methylbenzylamine as found in:

../rhodium/chemistry /reductive.alkylation.html


Reductive Alkylation of alpha-Methylbenzylamine with 1-Phenyl-2-Propanone Followed by Hydrogenolysis:

Nichols et al., Asymmetric Synthesis of Psychotomimetic Phenylisopropylamines, J. Med. Chem. 16(5) (1973) 480-3. This procedure offers a route to dextro-amphetamine from phenyl-2-propanone

 
 
 
 
    Rhodium
(Chief Bee)
05-22-02 02:19
No 312214
      RMgX + CuI + Imine -> Amine 99% yield, 99% ee  Bookmark   

Synlett 651 (2002) has a large review article of stereospecific addition of organometallic reagents to imines to form optically pure amines. It even includes some 2,5-dimethoxyphenyl compounds.
 
 
 
 
    PrimoPyro
(Hive Prodigy)
05-22-02 02:34
No 312221
      99% ee?  Bookmark   

99% ee? Does that mean 99% enantiomerically efficient by any chance? Just a wild guess.

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    Rhodium
(Chief Bee)
05-22-02 03:01
No 312235
      Enantiomeric excess
(Rated as: Good Explanation)
 Bookmark   

Enantiomeric excess. A racemic mixture is 0% ee, and a pure optical isomer is 100% ee. A 99% ee mixture consists of 99.5% of one isomer and 0.5% of the other. Stupid unit, I know.
 
 
 
 
    PrimoPyro
(Hive Prodigy)
05-22-02 03:09
No 312240
      Thank You  Bookmark   

I will remember this. The unit is ok, its value reminds me of the Proof system for alcohols, also redundant.

                                                 PrimoPyro

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