bottleneck (Hive Bee)
10-01-02 12:40
No 362679
      How do you condense a halide with a methyl ester?  Bookmark   

Regarding the SynGen proposed syntheses of lysergic acid from abrine, I presume "E" stands for "ester"?

In route G6, they condense 2,3-dihalopropionic acid and a methyl ester.

For example with methyl acetate, I guess the product should then be 2-(acetoxymethyl)-3-halopropionic acid.

Can anyone tell me which reaction would substitute a halo group with the methyl group of a methyl ester in this manner?