|Synthesis of benzodiazepines||Bookmark|
A general method is provided for the synthesis of substituted 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepi
Dedicated to weedar
There Can Only Bee One - xX www.the-hive.ws Xx
I happen to be in pharmacy scholl myself.
But if yu look under the klonazepam synthesis on rhodium's page you will find a preaparation of a 5-nitro, -2- chloro amino benzophenone.
Freidel crafts reaction between 2-chloro benzoyl choride, and a 4-nitroanaline.
using ZnCl2 as a Lewis acid catalyst.
the yeilds are low I suspect because of side reactions like the formation of an anilide, and multiple frediel crafts alkyltions.
but it's there.
I have a question once you have the bromacetamido chloro, nitro benzophenone, and you react it with hexamethylene tertamine in the presecne of an acid; what is the cycliization mechanism that produces your benzdazopinone?
Cyclization mechanisms can be tricky to decipher.
Spisshak: It might be found in ../rhodium/pdf /benzodiazepin