pickle11 (Stranger)
11-26-02 04:28
No 383362
      oihkal?  Bookmark   

correct me if im wrong.
1. tartaric acid can be isolated from cream of tartar.
2. tartaric acid can be reduced to succinic acid using I/H2S.
3. succinic acid can be neutralized with ammonium hydroxide and heated to form succinamide.
4. succinamide can be reacted ala ../rhodium/chemistry /nbs.html to yield n-bromosuccinamide
5. n-bromosuccinamide can be used ala ../rhodium/chemistry /ppa.synthesis.html to convert propenylbenzenes (asarone,anethole,isosafrole,isomyristicin,isoelemicin) into phenylpropanolamines
6. phenylpropanolamines can be reacted with cyanogen bromide to yield various ring substituted methylaminorex analogs. 
oxazolines i have known and loved.  I dont think any of them would be controlled substances or classified as analogs.
 
 
 
 
    Rhodium
(Chief Bee)
11-26-02 05:28
No 383371
      Yes, technically. But if you don't want to buy ...  Bookmark   

Yes, technically. But if you don't want to buy NBS, then please buy succinimide or at least succinic anhydride - those two are not watched the least. Aqueous bromine also does the same job as NBS, but not as cleanly (= lower yield). But a whole lot less work than your proposition, I promise.

Also, it is much easier to make aminorex analogs from PPAs using potassium cyanate than with cyanogen bromide - the former is non-toxic, the latter is a vile volatile poison.
 
 
 
 
    pickle11
(Stranger)
11-26-02 05:48
No 383379
      bromohydrine?  Bookmark   

what about the bromohydrine in the ppa synth.  is that repaceable, available, easily synthesized?
 
 
 
 
    Rhodium
(Chief Bee)
11-26-02 05:54
No 383382
      As I said, you can make that with aqueous bromine ...  Bookmark   

As I said, you can make that with aqueous bromine instead of NBS - UTFSE here or at http://patft.uspto.gov/netahtml/search-bool.html
 
 
 
 
    L42L
(Stranger)
12-04-02 00:22
No 385930
      Could you elaborate?  Bookmark   

I'm afraid I need more info. Searched a few key  words (or so i thought ) into TFSE and am at a loss.
Asarone-ppa ala aq Br !?! 
Any sugestions/hints/info/direction from any bee concerning this would be fab.

thanks,
lurk
 
 
 
 
    Rhodium
(Chief Bee)
12-04-02 11:30
No 386135
      Search for "bromohydrin".  Bookmark   

Search for "bromohydrin". Compounds with adjacent OH and Br groups are called that. Then you just select one of the preparations you find which doesn't use NBS.
 
 
 
 
    L42L
(Stranger)
01-17-03 19:56
No 399101
      help with succinic acid to succinamide  Bookmark   

Could some bee help with a theoretical procedure for this. Ammonium hydroxide and heat? The idea of synthing a new compound (even if it is a questionable aminorex) is thrilling to say the least. Thanks for the spark pickle11.

Thanks beez,
Lurk

BTW Rhodium: It aint much but its more than nothing. Its in the mail this weekend ($) Your efforts are truly priceless. Thanks!
 
 
 
 
    SPISSHAK
(Hive Addict)
01-17-03 20:16
No 399104
      I like that concept  Bookmark   

oxazolamines I have known and loved sounds like an intersting sequel to the phenylethylamines, too bad no one has done any research on the pharmacology or chemistry of ring substituded phenyloxazolamines.
 
 
 
 
    starlight
(Hive Bee)
01-18-03 12:34
No 399368
      just be aware of this  Bookmark   

Post 346726 (Dr_Heckyll: "4-Methylaminorex Dangers", General Discourse)