Drummer (Stranger)
12-12-02 06:20
No 388646
      Ergotamine Tartrate  Bookmark   

I am curious if there is a shelf life for this substance.
I have some considerably old Sandoz 1ml glass vials kicking around.
Thanks!

Understanding I know much less everyday.
 
 
 
 
    Rhodium
(Chief Bee)
12-12-02 06:33
No 388652
      shelf  Bookmark   

Yes, there is a shelf life as ET is decomposed by the usual culprits - heat, moisture and/or UV light. The exact time is hard to estimate as it depends wildly on how the samples were stored. A quick TLC analysis should reveal how fresh it is. If it has been stored in sealed vials the majority is likely still intact.
 
 
 
 
    Nemo_Tenetur
(Hive Bee)
12-14-02 11:05
No 389393
      Concentration ?  Bookmark   

What is the concentration? One mg per ml? I doubt that the total amount is more than a few mg.
 
 
 
 
    bbell
(Stranger)
01-12-03 22:47
No 397626
      lots of e.t. needed  Bookmark   

It takes a large amount of Ergotamine to make a quantity of lysergic acid. 10 grams to make 1/2 gram something like that
 
 
 
 
    Bubbleplate
(Hive Bee)
01-14-03 18:14
No 398117
      Actually, if one is careful  Bookmark   

you can get about 30-35% yield of LA from Ergotamine.
 
 
 
 
    Rhodium
(Chief Bee)
01-14-03 19:43
No 398145
      Yields  Bookmark   

It's very possible to get much better yields than that, here is a report of 75% yield (starting with ergocristine, another ergotamine): ../rhodium/chemistry /ergocristine.html

Also, the procedure in Tihkal gives high yields.
 
 
 
 
    bbell
05-25-03 01:22
      REMOVE THE SALT
(Rated as: ALL CAPS)
 Bookmark   
 
 
 
    Rhodium
(Chief Bee)
05-25-03 01:56
No 435276
      Why freebase and not the tartrate?  Bookmark   

You didn't give a complete reference, nor did you remember to let go of the shift key when typing.

Why do you feel it is important to use the freebase and not use the tartrate directly, as the basic conditions would release the freebase in situ anyway? Do you see any special reason potassium tartrate cannot be present in the solution while hydrolyzing?