flipper (Hive Bee)
12-16-02 18:15
No 390003
      LSD from LSA synth qeustion  Bookmark   

What's against this synth which is high yielding and easy?

(don't know the reference)

13,4 g dry LSA in 800 ml of DMF in a vacum flask @ 20C, you add a solution of N,N-Carbonyldiimidazole in 250 ml of DMF. Stir for one half hour @ 20C in the dark.
Add after that a solution of 4 g DEA in 50 ml of DMF.
Let stand for 2 hours @ 20C and then 20 hours @ 5C.
Evaporate in vacum to get the LSD.
Disolve in 2,5 L of 2% tartaric acid. Extract with Ether and discard Ether. Filter and basify with NH4OH and extract with a 9:1 ether:ethanol solution. Dry and evaporate in vacum to get LSD in 81% yield.


 
 
 
 
 
    raffike
(Hive Addict)
12-16-02 18:21
No 390004
      Dunno if it works but Carbonyldiimidazole is ...  Bookmark   

Dunno if it works but Carbonyldiimidazole is pretty cheap @ Fluka.

For those about to synth,we salute you
 
 
 
 
    Rhodium
(Chief Bee)
12-16-02 20:16
No 390032
      Carbonyldiimidazole is a well-known amide forming ...  Bookmark   

Carbonyldiimidazole is a well-known amide forming agent, so it seems just fine. You do need a pretty hefty vacuum to be able to evaporate DMF at room temp (or slightly above) though.
 
 
 
 
    PoohBearium
(Bear With Me)
12-16-02 20:47
No 390042
      DEA?  Bookmark   


Add after that a solution of 4 g DEA...




Heh, that's funny.  Must be diethylamide, right?

PB


Cocaine isn't habit forming. I should know - I've been using it for years.

Tallulah Bankhead
 
 
 
 
    Rhodium
(Chief Bee)
12-16-02 20:54
No 390043
      Close  Bookmark   

Almost, it's diethylamine, (C2H5)2NH.
 
 
 
 
    PoohBearium
(Bear With Me)
12-17-02 00:02
No 390084
      Aight  Bookmark   

I did second guess myself with it being an amine, but I went with the amide because of the "lysergic acid diethylamide" name.  Looks like a pretty simple molecule...

Is this the much sought after practical LSD wonder-synth?

smile

PB

*Can't wait to take gen chem 2 (will be analytical work, mostly), though I fear I have already forgotten most of what I knew about chemistry...  frown

Cocaine isn't habit forming. I should know - I've been using it for years.

Tallulah Bankhead
 
 
 
 
    cHiLLy
(Hive Bee)
12-17-02 00:11
No 390088
      alight  Bookmark   

I had never heard CDI (N,N-Carbonyldiimidazole) being mentioned as a coupling reagent for L synth. That does seem very simple!
Heres another peptide coupling reagent that ive never heard discussed...1-Hydroxy-7-azabenzotriazole, HOAT. any possibilities there?
 
 
 
 
    Lilienthal
(Moderator)
12-17-02 13:59
No 390206
      e.g. UTFSE :-)  Bookmark   

e.g. UTFSE smile
 
 
 
 
    Dexter666
(Stranger)
12-21-02 09:10
No 391359
      Wow!  Bookmark   

Ok, so this is a valid synth from LSA to LSD using simple methods like mixing and stirring?

Just say NO to police searches!
 
 
 
 
    Rhodium
(Chief Bee)
12-21-02 14:05
No 391403
      No, the procedure is far from complete, lacking ...  Bookmark   

No, the procedure is far from complete, lacking every possible detail about the mandatory chromatographic purification, as well as the need to perform large parts of the synthesis under darkroom conditions, LSD being very light sensitive, especially in solution.
 
 
 
 
    cHiLLy
(Hive Bee)
12-22-02 08:14
No 391638
      Im sure that theres other obstacles..  Bookmark   

Im sure that theres other obstacles..unfortunately theres very few first hand reports to go on. Like he said theres the chromatography and of course getting LSA is not easy either.
BTw, wasnt it determined around here that the photodecomposition isnt as considerable with large amounts?
 
 
 
 
    tryptych
12-24-02 23:06
      purification
(Rated as: misinforming)
 Bookmark   
 
 
 
    PoohBearium
(Bear With Me)
12-24-02 23:52
No 392550
      Ummm...  Bookmark   

...toxicity?

PB

Fuck you, you bisexual midget fucking dwarf!!!
 
 
 
 
    spooky1234
(Stranger)
12-25-02 08:21
No 392652
      Read LSD purity on www.erowid.org.  Bookmark   

Read LSD purity on www.erowid.org. Impurities do seem to effect the trip significantly. And iso-lsd can be converted into d-lsd easily. So there is no reason not to.
 
 
 
 
    pashov
(Stranger)
01-26-03 13:22
No 401574
      aminating agent?  Bookmark   

I don't understand the role of the "aminating agent" in this synth. Why does anything need to be aminated in lysergic acid amide?

Well, I'm probably just stupid, does anybody know some references where I could read up on Carbonyldiimidazole and its use? Possibly with nice reaction diagrams and stuff...

Does somebody have references to other LSA -> LSD routes? The one on rhodium.ws looks promising, but is there anything else besides going back from LSA to lysergic acid?
 
 
 
 
    flipper
(Hive Bee)
02-01-03 14:14
No 403242
      The solvent  Bookmark   


13,4 g dry LSA in 800 ml of DMF




Is it possible to use less solvent without effecting the yield?
Is it possible to use another solvent then DMF?