pHarmacist
(Hive Addict)
01-30-03 16:47
No 402816
      Cobalt-Catalyzed Total Synthesis of ()-LSD
(Rated as: excellent)
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Abstract: Cocyclization of 4-ethynyl-3-indoleacetonitriles with alkynes in the presence of CpCo(CO)2 gives rise to the ergoline derivatives 6-9, two of which were transformed into racemic lysergene and LSD, respectively.

See full-text at:

http://pharmacist8.tripod.com/ergot.pdf

Reference: Synlett 1994; 487-489

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    YourMomma7111
(Stranger)
02-03-03 08:35
No 404006
      That paper is elegant & beautiful!  Bookmark   

Note that, in conversion from compound 9 to compound 10, one could substitute CF3SO3Et in THF at O degrees Celsius and end up with ETH-LAD (alkyl N-ethylated LSD-025) instead of LSD, which is a much dirtier drug than the former, although on a microgram to microgram scale the two are of about equipotentcies.
 
 
 
 
    EtHeRpEeKeR
02-11-03 02:52
      Yessiree, went right over my head,
(Rated as: off-topic)
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