mysterious (Stranger)
02-26-03 04:53
No 411914
      proscaline  Bookmark   

hi all friends!!

anyone every tried proscaline (p)?? i read of it in shulgins book!! do you know if this substance can be made of any uncontrolled substances??

anyone who tried it: how would  you describe the effects??

nice greetings!!
mysterious
 
 
 
 
    Barium
(Hive Addict)
02-26-03 05:46
No 411926
      Route  Bookmark   

Syringaldehyde is alkylated with propyl iodide to 3,5-dimethoxy-4-propoxybenzaldehyde, the benzaldehyde is reacted with a chloroacetic acid ester in a Darzens condensation to give (3,5-dimethoxy-4-propoxyphenyl)acetaldehyde. This acetaldehyde can be reductively aminated with ammonia and Raney nickel, or the aldoxime formed with hydroxylamine which is then reduced to the amine proscaline (3,5-dimethoxy-4-propoxyphenethylamine). All reagents here are pretty unwatched.

Freaky
 
 
 
 
    Rhodium
(Chief Bee)
02-26-03 16:05
No 412081
      syringaldehyde from vanillin  Bookmark   

And syringaldehyde is easily made from vanillin: ../rhodium/chemistry /mmda.mescaline.html
 
 
 
 
    Antoncho
(Official Hive Translator)
02-26-03 22:14
No 412177
      Questions, questions.  Bookmark   

the benzaldehyde is reacted with a chloroacetic acid ester in a Darzens condensation to give (3,5-dimethoxy-4-propoxyphenyl)acetaldehyde. This acetaldehyde can be reductively aminated with ammonia and Raney nickel

Mmmmm, can you elaborate on that? Ever done this? I mean, you once wrote you were going to, but thus far all i read from you was on P2Ps via chloropropionates. Maybee, i should UTFSE better?

I always had a notion of this method as of somehow untrustworthy since those acetaldehydes would bee very hard to keep from polymerisation.... no?


Antoncho
 
 
 
 
    Rhodium
(Chief Bee)
02-26-03 22:33
No 412180
      Reductive amination of phenylacetaldehydes  Bookmark   

See Patent US5057624.
 
 
 
 
    hypo
(Hive Addict)
02-27-03 00:53
No 412207
      easy is relative  Bookmark   

> And syringaldehyde is easily made from vanillin:

iirc some bees (antoncho?) have had problems with the
methoxylation step.

uemura had big problems separating OH-vanillin from vanillin.
(ok, that's not syringaldehyde, but related)

i don't consider those syntheses "easy".
(for otc-bees. now if you have high grade chemicals it's probably a breeze...)