Xicori (Hive Bee)
02-28-03 02:25
No 412514
      AMT Synthesis  Bookmark   

High Bees!!

Swim got his hands on some amount of Indole-3-Aldehyde - so he wants to try the AMT-Synthesis...

At Rhodium there can be found two preperations for the 1st step (alpha-Methyl-beta-indolenideniumethyl Nitronate) - In this step the aldehyde is condensed with nitroethan using dibasic ammonium phosphate or Ac2O, GAA and ammonium acetate...

Now my Question:
Why ammonium phosphare or acetic anhydride is needed in this synthesis? wouldnt it also work to just use sodium acetate and GAA as solvent? - dibasic ammonium phosphate doesnt sound to be very hard to get - is in available OTC somewhere?

Have a nice weekend! laugh

02-28-03 02:49
No 412517
      Ammoniumacetate / acetic acid definitely ...  Bookmark   

Ammoniumacetate / acetic acid definitely works, no need to use acetic acid anhydride. There are way better catalysts around for perfectionists, but it works.