MistaMiyagi (Stranger)
03-27-03 21:02
No 421898
      18-methoxycoronaridine (18-MC)  Bookmark   

Just got my issue of Discover today... interesting popular-language overview of ibogaine and its cogener, 18-methoxycoronaridine.

18-MC, according to the article, presents some of the addiction-quelling properties of ibogaine without ibogaine's side effects.  Don't know if this would be of use to anyone... I am still teaching myself o-chem and thought someone may wish to try and synth/taste/research this.  A WebCrawl for 18-methoxycoronaridine found this blurb:

...18-methoxycoronaridine exerts its anti-addictive effects via a reversal of the neuroadapations mediating increased incentive salience for drugs of abuse...

  Maybe in addition to its apparent anti-addiction potential, could it be used by hedonists (read: people like me) to resensitize the CNS to 5-HT-ergic and DA-ergic (read: almost any enjoyable) drugs?

The article:
Abrams, Michael.  "The End Of Craving."  Discover May 2003 (vol. 24 : no. 5) pgs 24-5.

Page of citations of 18-MC research:

*** If this is simply an illusion, does that mean hallucinations are reality? ***
(Chief Bee)
03-28-03 10:04
No 422036
      No go...  Bookmark   

Ibogaine is pretty much unsynthesizable, I have only seen one preparation of it in the literature, and that one comprised 35 steps or something in total...
(Hive Addict)
03-28-03 20:30
No 422163
      Ibogaine: A Novel Anti-Addictive Compound  Bookmark   

A Comprehensive Literature Review to bee found at: http://userpages.umbc.edu/~jfreed1/Ibogaine.html

Here is it in PDF format: http://userpages.umbc.edu/~jfreed1/Ibogaine.pdf

Accept No Imitations, There Can Only Bee One; www.the-hive.ws
(Hive Addict)
03-28-03 22:13
No 422178
      2C-I  Bookmark   

This makes me wonder if not 2C-I should be classified as an oneirogenic material?

Accept No Imitations, There Can Only Bee One; www.the-hive.ws
(I'm Yust a Typo)
03-29-03 02:49
No 422231
      Yup, I've noticed this on 2C-I too.  Bookmark   

Yup, I've noticed this on 2C-I too. Depends a lot on setting. Other materials (2C-E) have this property too.