silenziox (Stranger)
03-28-03 15:12
No 421995
      MDMA & MDA mixture in one rxn  Bookmark   

1. Could mdp2p be aminated to yield both MDA and MDMA
   on one run? I was thinking of the Leuckart rxn, where
   either the ammonium formate/methylammonium formate is
   substituted with mixture of both to achieve the
   favorable ratio for swim.

2. SWIM was wondering after one-night-searching-w/TFSE and
   if there is any method for converting piperonal to
   mdp2p without the nitropropene-step.. With a good
   yield of course wink

(Btw, Rhodium, the document at
../rhodium/pdf /isosafrole.electrooxidation.pdf doesn't exist...)

Was the high as good for you as it was for me?
 
 
 
 
    Rhodium
(Chief Bee)
03-28-03 18:59
No 422035
      That is because I have that article in HTML...  Bookmark   

That is because I have that article in HTML format at ../rhodium/chemistry /isosafrole.electro.html now.

Barium has posted nice preparations of phenylacetones from benzaldehydes using the Darzen Condensation.

It is always a bad idea to try to produce a mixture of products at the same time. How are you going to purify it? It is hard enough to do even with only a single product.
 
 
 
 
    silenziox
(Stranger)
03-29-03 09:02
No 422213
      Hard work  Bookmark   



It is always a bad idea to try to produce a mixture of products at the same time. How are you going to purify it? It is hard enough to do even with only a single product.



Thanks for the link of the html-article smile
Why is it that all bees buzz that Leuckart synth is
hard-to-do-synth? I found it to be the easiest synth
(with best yields, thanks to Zealot's improvement!) to
make mda/mdma..

Or did you mean it's hard to purify even single product
at a time? ... How hard could it be if washed with acetone
in buchner?

Was the high as good for you as it was for me?
 
 
 
 
    raffike
(Hive Addict)
03-29-03 13:37
No 422250
      How hard could it be if washed with acetone in  Bookmark   

How hard could it be if washed with acetone
in buchner?

Well,acetone shouldn't be considered some wonder cure-all.N-methylformamide gives lower yield than formamide so you probably don't know how much MDA or MDMA it contains without analysis.

For those about to synth,we salute you
 
 
 
 
    Rhodium
(Chief Bee)
03-29-03 18:58
No 422300
      Leuckart impurities  Bookmark   

Here below is a review of impurities specific to the Leuckart reaction in the synthesis of amphetamine and methamphetamine. One could very likely assume that similar impurities are present in MDMA and MDA prepared by the same reaction.

http://www.undcp.org/odccp/bulletin/bulletin_1984-01-01_1_page006.html

I think it is extremely naive to assume that all those could be removed by a simple acetone wash. You need to distill the freebase and recrystallize the final hydrochloride to remove the majority of them. And the efficiency of both these purification protocols will be inhibited by using a mixture of MDA and MDMA...
 
 
 
 
    madprosr
(Hive Bee)
03-29-03 20:25
No 422318
      gassing mixture of freebases?  Bookmark   

if one gasses a mixture of mda/mdma freebase in toluene, would they get a more homogenous mixture of the two amine salts than if the salts were dried first then ground together?
 
 
 
 
    Rhodium
(Chief Bee)
03-30-03 00:06
No 422350
      The mixture would be LESS homogenous if gassed  Bookmark   

The mixture would be LESS homogenous if gassed together than if mixed as powders and sieved through a mesh.
 
 
 
 
    SPISSHAK
(Hive Addict)
03-30-03 22:15
No 422570
      I'm not exactly sure if this is true  Bookmark   

You can ask Sam ( I think he mentioned this too) but I think the leukart synthesis when applied to methylenedioxyphenylacetone is more likely to give pyrimidines than the unsubstitued counterpart, as a result isn't an optimal way to produce substitued methamphetamines like this. BTW Rhodium that is an excellent article that belongs on your page.