spike_heron (Stranger)
04-20-03 04:22
No 428174
      Nichols papers to post?  Bookmark   

i just nabbed the following papers, and would be more than happy to post them if a) there is a significant amount of interest, and b) you can find me somewhere to UL them to so that they can be referenced in a URL.

J. Med. Chem. 1997, 40, 2997-3008
Dihydrobenzofuran Analogues of Hallucinogens. 4.1 Mescaline Derivatives2

Bio. Med. Chem. Lett. 11 (2001) 793795
A Novel Fluorinated Tryptamine with Highly Potent Serotonin
5-HT1A Receptor Agonist Properties

Bio. Med. Chem. Lett. 12 (2002) 19971999
Translocation of the 5-Alkoxy Substituent of 2,5-Dialkoxyarylalkylamines to the 6-Position: Effects on 5-HT2A/2C Receptor Affinity

J. Med. Chem. 2000, 43, 4701-4710
Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines

J. Med. Chem. 2001, 44, 1003-1010
Enantiospecific Synthesis and Pharmacological Evaluation of a Series of Super-Potent, Conformationally Restricted 5-HT2A/2C Receptor Agonists

J. Med. Chem. 2002, 45, 4344-4349
Lysergamides of Isomeric 2,4-Dimethylazetidines Map the Binding Orientation of the Diethylamide Moiety in the Potent Hallucinogenic Agent N,N-Diethyllysergamide (LSD)

J. Med. Chem. 1998, 41, 2134-2145
Substituted Naphthofurans as Hallucinogenic Phenethylamine-Ergoline Hybrid Molecules with Unexpected Muscarinic Antagonist Activity

J. Med. Chem. 1998, 41, 4995-5001
Synthesis and Serotonin Receptor Affinities of a Series of trans-2-(Indol-3-yl)cyclopropylamine Derivatives

J. Med. Chem. 1998, 41, 5148-5149
A Novel (Benzodifuranyl)aminoalkane with Extremely Potent Activity at the 5-HT2A Receptor

J. Med. Chem. 1999, 42, 1106-1111
Thieno[3,2-b]- and Thieno[2,3-b]pyrrole Bioisosteric Analogues of the Hallucinogen and Serotonin Agonist N,N-Dimethyltryptamine

also, i happily take requests, if youre just itching to find that journal article.

(Hive Bee)
04-20-03 04:44
No 428176
      yes!!  Bookmark   

I'd like to have 2, 4 and 7 . (in fact I'd like to have 'em all, don't have access to J. Med. Chem. here)

(Hive Bee)
04-20-03 06:14
No 428185
      You have found some pretty interesting ...  Bookmark   

You have found some pretty interesting articles. If you would like to upload them just go to Geocities and sign up. You will get some web space for free and you can upload your articles using instructions on that page.

Edit: Or you can put them in text format and post some procedures here. I'm sure you will get some good karma points for that.

I'm dreaming of the white crystals.
(Official Hive Translator)
04-20-03 06:15
No 428186
      Yeeeesss!  Bookmark   

Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT2A/2C receptor affinity

James J. Chambers, Deborah M. Kurrasch-Orbaugh and David E. Nichols

Bioorganic & Medicinal Chemistry Letters Volume 12, Issue 15 , 5 August 2002, Pages 1997-1999

Abstract: Positional modification of 2,5-dimethoxyamphetamine analogues has been studied. Specifically, the 5-alkoxy substituent was translocated to the 6-position of the phenyl nucleus. Methoxy groups were also constrained by incorporation into appended dihydrofuran and furan rings. 2,6-Dimethoxy-4-methylamphetamine had an approximately 3-fold lower affinity for the 5-HT2A receptor compared to the parent 2,5-dimethoxy-4-methylamphetamine (DOM). The rigid compound based on the 2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran nucleus and the aromatic analogue containing the benzo[1,2-b;5,4-b']difuran nucleus possessed an approximate 7- and 27-fold increase in affinity, respectively, compared to 2,6-dimethoxy-4-methylamphetamine, the non-rigid, positional isomer.

And i'd really like to take a look at the above..... Sasha's 'pseudo' series, almost non-explored up to date.

04-20-03 06:44
No 428191
      well, give me a couple days  Bookmark   

i got papers to write at the moment. give it a couple days and ill get some web space and link them. additionally, antoncho, you can ask him yourself at mindstates, either nichols or sasha, about their activity in man. or maybe i will. ;)
04-20-03 20:14
No 428294
      okay, here we go  Bookmark   

i havent sorted these by filename. i figure what the hell, people are going to kill the geocities bandwidth almost immediately anyways, so why bother. dl them all and see for yourself.


have fun, guys.
(Hive Bee)
04-20-03 21:54
No 428307
      RE: Nichols papers  Bookmark   

You are right they are gone .......good effort though maybe there is another way, maybe some bee will come up with a place to put them.......hold on......java

We're  all in this world together,
(Hive Bee)
04-21-03 03:16
No 428342
      you can get them from here too  Bookmark   

If you can't access them from the above links, then try from here:


(Hive Addict)
04-21-03 14:12
No 428463
      Typing  Bookmark   

Hey Rhodium, do you want any of these typed up?  are you just going to link the pdf file as-is?
(Chief Bee)
04-21-03 14:48
No 428472
      Now at my page  Bookmark   

I have transferred all the working PDF files from above to my Dave Nichols Archive (../rhodium/pdf /nichols/) along with a few I had myself - if anyoneone has any further articles co-authored by Nichols, please make them available to me for inclusion in that directory.

Thanks Aurelius, but not at the moment, as I think his articles are better read in their entirety. I'll PM you some other ones which could be converted instead.