cattleprodder (Hive Bee)
05-14-03 12:09
No 433155
      oil of mugwort  Bookmark   

Does anyone know off hand the percent composition of
3,5-dimethoxy-1-allylbenzene in the somewhat expensive but nevertheless commercially available oil of mugwort? 

Shulgin makes a passing reference to the presence of the aforementioned essential oil under the Essential Spice Oil discussion in Pihkal (under TMA), saying that the oil itself is a reputed stimulant and opiate poisoning antidote according to traditional folklore.

I can only imagine what 3,5-dimethoxyamphetamine would be like, but I must admit to being a 1,3,5 / 2,4,6 120 degree bond angle trisubstitution pattern junkie as THC and TMA-6 both enthrall me, not unlike Tantalus the fox and his proverbial bunch of flavonoid containing grapes.
 
 
 
 
    cattleprodder
(Hive Bee)
05-14-03 12:39
No 433163
      Was Shulgin wrong?  Bookmark   

I just did a quick search for the percent composition of the oil of mugwort and it apparently contains alpha and beta thujone as its essential oils.  STAY AWAY.

Anyway, 3,5-dimethoxybenzaldehyde is only about 70 USD for 10 grams.
 
 
 
 
    phase_dancer
(Stranger)
05-14-03 20:09
No 433242
      I've often wondered about this.  Bookmark   

I've often wondered about this. Apart from Shulgins mention I've seen nothing on any activity of 3,5 dimethoxy PEA's or amphetamines.

Placing fresh mugwort in a pillow makes for amazing dreams. I assume this is mainly due to the thujone
 
 
 
 
    Rhodium
(Chief Bee)
05-15-03 03:56
No 433309
      3,5-Dimethoxyphenethylamine Activity  Bookmark   

According to J. Org. Chem. 23(12), 1979-1984 (1958) (../rhodium/pdf /activity.of.subst.peas.in.cats.pdf) 3,5-Dimethoxyphenethylamine is completely devoid of entheogenic effects in a study made on cats. It can probably be assumed that the 3,5-Dimethoxyamphetamine analog isn't that fun either.

However, the article do list several other compounds which could be of interest; such as 3,5-Dibromo-4-methoxy-PEA, 3,5-Dimethyl-4-methoxy-PEA and 3,4,5-Trimethyl-PEA. I think the preparation of all these compounds has already been posted here on the Hive.
 
 
 
 
    phase_dancer
(Stranger)
05-15-03 19:19
No 433458
      Interesting read  Bookmark   

Thanks Rhodium

At the dosage used (25mg/kg intramuscular) those compounds may certainly warrant further investigation.


After reading GPig2's post on Post 370205 (GPig2: "4-isobutyl-3,5-dimethoxy-PEA = POISON", Serious Chemistry) I wondered whether other 4th position substitutes may have been tried. I don't really understand why the 3,5-methoxy amines would be thought to be opioid antagonists, but then again my SAR knowledge is somewhat limited.