Aurelius
(Hive Addict)
06-13-03 09:20
No 439780
      Compilation on GHB/GBL
(Rated as: excellent)
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Compilation for GBL and GHB

Preparation of salts of GHB/GBL
../rhodium/chemistry /ghb-r-us.txt

GABA to GHB
Post 394630 (Chromic: "Success making GBL!", Chemistry Discourse)
Post 364288 (Rhodium: "GABA -> GBL + GHB", Chemistry Discourse)
Comment on distillation of GBL from this particular reaction mixture:
Post 375796 (Rhodium: "If you acidify the solution slightly (pH 4-6), ...", Chemistry Discourse)
Physical Properties of GABA:
Post 375570 (Chromic: "Question your GABA", Chemistry Discourse)
Note on the Formation of Nitrosamines in this Rxn:
Post 378237 (fierceness: "nitrosamines", Chemistry Discourse)
Post 412468 (hCiLdOdUeDn: "Nitrosamine decontamination", Chemistry Discourse)

GBL, 1,4-butanediol, and THF
Post 414046 (roger2003: "German Dissertation about industrial scale...", Chemistry Discourse) (in german)
../rhodium/chemistry /gbl.synthesis.microgram.html

GBL from 1,3-Propanediol
Post 489813 (Rhodium: "GBL synthesis starting from 1,3-Propanediol", Methods Discourse)

GBL/GHB from 1,4-butanediol
Oxid. with NaOCl and RuCl2
Post 444525 (Vitus_Verdegast: "I'm in a typ-o-maniacal mood today  ;-)", Methods Discourse)
Oxidation with Permanganate:
Post 243620 (foxy2: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
Oxid. to GBL with various reagents
Post 441399 (Rhodium: "1,4-BD -> GBL (76%) w/Trichloroisocyanuric Acid", Methods Discourse)
Post 441437 (Rhodium: "Chem. Abs. 130:24638.", Methods Discourse)
Post 441438 (Rhodium: "Chem. Abs. 130:313445", Methods Discourse)
Post 442866 (Rhodium: "1,4-BD -> GBL (92%) using NaBrO2/Alumina", Methods Discourse) (typed version next)
Post 443378 (Vitus_Verdegast: "article typed up", Methods Discourse)
Reaction with N-Haloamides:
Post 246415 (Rhodium: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
Dehydrogenation of the Diol:
../rhodium/chemistry /bd2gbl.html
Post 441834 (Rhodium: "1,4-Butanediol to gamma-Butyrolactone in French", Methods Discourse)  (in french, same as next link)
Post 441898 (GC_MS: "1,4-Butanediol to gamma-Butyrolactone in English", Methods Discourse)(in english)
Post 449422 (Rhodium: "Maybe activation by pre-reduction is needed?", Chemistry Discourse) (dehydrogenation catalyst information/idea)
Oxid. with Hypohalite:
../rhodium/pdf /bd2gbl.pdf
Other References for Use of Diol:
../rhodium/chemistry /bdo2gbl.html
Synthesis of 1,4-butanediol
Patent US6486367
Patent US6100410
Post 471608 (Rhodium: "Maleic Anhydride + BDO -Zn/Cu-> 2 GBL", Novel Discourse)


GBL/GHB from THF
Oxidation with Bromate:
Post 214379 (foxy2: "Re: New(?) angle on THF > GBL", Chemistry Discourse)
../rhodium/pdf /thf2gbl.pdf  (includes mechanism)
Post 242315 (Rhodium: "Easy Oxidation of THF to GBL", Novel Discourse)
Post 243615 (foxy2: "a multi-purpose oxidant", Novel Discourse)
Experience with ox. bromate/H2O2
Post 474583 (Beeswax: "Modification:  Bromate oxidation  THF -> GBL", Methods Discourse)

Oxid. with Trichloroisocyanuric acid
Post 444004 (Aurelius: "Trichloroisocyanuric acid, ethers to esters", Methods Discourse)
Post 446457 (Aurelius: "Ether Oxid. Tet. 27, 2671-2674, (1971) THF-GBL", Methods Discourse)
Post 340852 (Captain_Mission: "GBL from THF using trichloroisocyanuric acid", Novel Discourse)
Oxidation with Permanganate:
Post 243620 (foxy2: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
../rhodium/pdf /solventfree.kmno4.oxidation.pdf
Experience with a permanganate oxidation:
Post 304838 (Antimony: "Cheap Easy GHB -No Bromate", Newbee Forum)
Oxid. wth Fe+2:/I]
Post 243627 (foxy2: "Ultimate Easy and Cheap THF to GBL", Novel Discourse)
[I]Oxid. wth Peroxyphosphoic acid:/I]
Post 243635 (foxy2: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
[I]Oxid. wth Br2:

Patent US3074964
Catalytic Oxid. with O2:
Post 364181 (moo: "Catalytic oxidations of THF with 1 atm O2", Methods Discourse)
Oxid. with CoCl2: Not suggested b/c of nature of oxidant
Post 364181 (moo: "Catalytic oxidations of THF with 1 atm O2", Methods Discourse)
Oxid. with Calium Hypochlorite
Post 3958 (Fuchem: "Oxidation of THF to GBL from Tetrahedron Letters", Chemistry Discourse)
Electro-synthesis of GBL from THF:
Post 243610 (foxy2: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
Very similar to the above (from patent SU523093):
Post 381459 (moo: "THF -> GBL patents etc.", Methods Discourse)
Patent US3074964
Other References for THF to GBL/GHB:
../rhodium/chemistry /thf2gbl.html

GHB/GBL from Succinic and Maleic acids and anhydrides
Bunch of US patents related:
Post 225945 (encopo: "GHB via GBL/THF via MAN via n-butane", Serious Chemistry)
Post 466341 (Rhodium: "Reduction of Succinic Anhydride to GBL", Methods Discourse)
Post 471608 (Rhodium: "Maleic Anhydride + BDO -Zn/Cu-> 2 GBL", Novel Discourse)

GHB/GBL from Cyclobutanone
Just an idea
Post 67503 (Teonanacatl: "Cyclobutanone --> GHB", Novel Discourse)

GBL from GHB
Post 511270 (Rhodium: "Convenient Synthesis of γ-Butyrolactone", Chemistry Discourse)

Physical Properties and Detection of GHB and GBL

Physical Properties and Detection of GHB
../rhodium/pdf /ghb-gbl.colortest.pdf
../rhodium/chemistry /ghb.forensic.html
Chromicís Use of the above method for GHB determination (both links):
Post 377846 (Chromic: "What the fuck???", Chemistry Discourse)
Post 377847 (Chromic: "Dilution was the key", Chemistry Discourse)


Physical Properties and Detection of GBL
../rhodium/pdf /ghb-gbl.colortest.pdf
../rhodium/chemistry /ghb.forensic.html
Post 449374 (Rhodium: "Cu Chromite dehydrogenation of 1,4-BD and GBL", Chemistry Discourse)
Post 449918 (LaBTop: "GBL MSDS", Newbee Forum)

Purification of GBL/GHB
Post 214381 (foxy2: "PURIFICATION OF GAMMA-BUTYROLACTONE", Chemistry Discourse)

Misc. Stuff I havenít organized yet:
Enzyme stuff
Post 317357 (Chromic: "Some GHB/BDO answers (sorry for the delay...)", Chemistry Discourse)
../rhodium/chemistry /ghb.html  Has information on analogues
Post 446659 (OcoteaCymbarum: "Uses for gbl", Chemistry Discourse)
Post 446714 (OcoteaCymbarum: "Industrial production of gbl", Methods Discourse)



Analogues:
../rhodium/chemistry /ghb.html 
4-methyl-GHB:
../rhodium/chemistry /4-methyl-ghb.html
MAB and DABD:
../rhodium/chemistry /mab.dabd.html

Articles and Arguments For and Against GHB
Post 412696 (runne: "Great article of GHB.", General Discourse)
One of the best write-ups I have personally EVER seen (thanks pharmacist):
Post 403259 (pHarmacist: "Thruth About GHB! -DEA, Give Up, you Look Stupid!", General Discourse)
Five part Article:
Post 405869 (raffike: "LOTS of info about GHB", General Discourse)
Post 405870 (raffike: "In his 1969 review on GHB, anaesthesiologist...", General Discourse)
Post 405871 (raffike: "Mamelak has also noted the unique ability of...", General Discourse)
Post 405872 (raffike: "GHB has been shown to induce major increases...", General Discourse)
Post 405873 (raffike: "In the course of mitochondrial ATP bioenergy...", General Discourse)
Post 317348 (Chromic: "GHB: Wernicke-Korsakoff syndrome", General Discourse)
Post 317402 (placebo: "Alternative names: Korsakoff psychosis; alcoholic ...", General Discourse)
Post 435795 (Rhodium: "Therapeutic GHB does not cause withdrawal", General Discourse)
http://www.projectghb.org/while_sleeping/sld001.htm

Addiction to GHB:
http://www.erowid.org/chemicals/ghb/ghb_addiction2.pdf

Pharmacology
../rhodium/pharmacology/index.html  (look under the GHB heading)
Post 275360 (Rhodium: "Re: DopamineReplenishment", General Discourse)
Same as above:
../rhodium/pharmacology/ghb/ghb.a.new.and.novel.drug.of.abuse.pdf
Dosage:
Post 257448 (MaDMAx: "Re: GHB vs GBL ???", Newbee Forum)
THF contamination and its toxicity
Post 490525 (7is: "Pharmacology of  Tetrahydrofuran", General Discourse)
Post 499157 (jsorex: "Copyright © 1996 American Academy of Neurology", General Discourse)

Wanted References of Relevance:
Gouesnard, Jean-Paul; BSCFAS; Bull.Soc.Chim.Fr.; FR; 1; 1989; 88-94 (GHB from GABA)
Tetrahedron Lett. 1968, page 5819; Tetrahedron 1971,vol 27, page 2671
References for Various Oxid. Reagents for use on THF:
Post 67703 (SpicyBrown: "Re: New(?) angle on THF > GBL", Chemistry Discourse)

Act quickly or not at all.